| Gene Information | |
|---|---|
| Gene Name | SLC22A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 555 |
| Protein Names | Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000112499 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15244 |
| Gene Card | SLC22A2 |
| Uniprot ID | O15244 |
| Pfam | PF00083 |
| In ASD | yes |
| Allosteric Prediction | yes (0.607680654) |
| Ortholog in Animals | Alpaca_ SLC22A2 ( ortholog_one2one ) Dog_ SLC22A2 ( ortholog_one2one ) GuineaPig_ SLC22A2 ( ortholog_one2one ) Macaque_ SLC22A2 ( ortholog_one2one ) Mouse_ Slc22a2 ( ortholog_one2one ) Pig_ SLC22A2 ( ortholog_one2one ) Rat_ Slc22a2 ( ortholog_one2one ) Rabbit_ SLC22A2 ( ortholog_one2one ) |
| Ohnologs | SLC22A8, SLC22A11, SLC22A25, SLC22A6, SLC22A13 |
| Paralogs | SLC22A24, SLC22A12, SLC22A1, SLC22A6, SVOP, SLC22A17, SLC22A7, SLC22A11, SLC22A23, SLC22A25, SLC22A15, SLC22A9, SLC22A4, SLC22A5, SLC22A3, SLC22A16, SLC22A8, SVOPL, SLC22A31, SLC22A13, SLC22A14, SLC22A10 |
| Tissue | kidney |
| Tissue Specificity | Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. {ECO:0000269|PubMed:11912245, ECO:0000269|PubMed:17393420, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9687576}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs8177504 rs8177507 rs145450955 rs316019 rs8177513 rs8177516 rs8177517 rs3907239 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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