| Gene Information | |
|---|---|
| Gene Name | TJP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 919 |
| Protein Names | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000105289 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O95049 |
| Gene Card | TJP3 |
| Uniprot ID | O95049 |
| Pfam | PF00625; PF00595; PF07653 |
| In ASD | no |
| Allosteric Prediction | no (-1.000087219) |
| Ortholog in Animals | Alpaca_ TJP3 ( ortholog_one2one ) Dog_ TJP3 ( ortholog_one2one ) Macaque_ TJP3 ( ortholog_one2one ) Mouse_ Tjp3 ( ortholog_one2one ) Pig_ TJP3 ( ortholog_one2one ) Rat_ Tjp3 ( ortholog_one2one ) |
| Ohnologs | TJP1, TJP2 |
| Paralogs | DLG5, TJP2, TJP1 |
| Tissue | appendix, colon, gall.bladder, lung, parotid.gland, seminal.vesicle, submandibular.gland, vas.deferens, small.intestine |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3KFV (X-ray 2.80A ) |
| DBSNP | rs1046268 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21411630}; Peripheral membrane protein {ECO:0000269|PubMed:21411630}; Cytoplasmic side {ECO:0000269|PubMed:21411630}. Cell junction, tight junction {ECO:0000269|PubMed:21411630, ECO:0000269|PubMed:23608536}. Nucleus {ECO:0000269|PubMed:23608536}. Note=Exhibits predominant nuclear expression in proliferating cells but is exclusively junctionally expressed after confluence is reached (PubMed:23608536). Shows an epithelial-specific tight junction localization in a TJP1/TJP2-dependent fashion (By similarity). {ECO:0000250|UniProtKB:Q9QXY1, ECO:0000269|PubMed:23608536}. |
| Mouse PG classification | NA |
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