| Gene Information | |
|---|---|
| Gene Name | CNIH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 160 |
| Protein Names | Protein cornichon homolog 2 (CNIH-2) (Cornichon family AMPA receptor auxiliary protein 2) (Cornichon-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000174871 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6PI25 |
| Gene Card | CNIH2 |
| Uniprot ID | Q6PI25 |
| Pfam | PF03311 |
| In ASD | yes |
| Allosteric Prediction | yes (0.280790501) |
| Ortholog in Animals | Alpaca_ CNIH2 ( ortholog_one2one ) Dog_ CNIH2 ( ortholog_one2one ) GuineaPig_ CNIH2 ( ortholog_one2one ) Macaque_ CNIH2 ( ortholog_one2one ) Mouse_ Cnih2 ( ortholog_one2one ) Rat_ Cnih2 ( ortholog_one2one ) |
| Ohnologs | CNIH1, CNIH3 |
| Paralogs | CNIH3, CNIH1, CNIH4, PPCS |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:23103966}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}. |
| Mouse PG classification | NA |
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