| Gene Information | |
|---|---|
| Gene Name | MAP3K10 |
| Organism | Homo sapiens (Human) |
| Gene Length | 954 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) |
| Target Name | mixed lineage kinase 2 |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000130758 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q02779 |
| Gene Card | MAP3K10 |
| Uniprot ID | Q02779 |
| Pfam | PF07714; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.256465647) |
| Ortholog in Animals | Alpaca_ MAP3K10 ( ortholog_one2one ) Dog_ MAP3K10 ( ortholog_one2one ) GuineaPig_ MAP3K10 ( ortholog_one2one ) Macaque_ MAP3K10 ( ortholog_one2one ) Mouse_ Map3k10 ( ortholog_one2one ) Pig_ MAP3K10 ( ortholog_one2one ) Rat_ Map3k10 ( ortholog_one2one ) Rabbit_ MAP3K10 ( ortholog_one2one ) |
| Ohnologs | MAP3K9, MAP3K20, MAP3K21, MAP3K11 |
| Paralogs | LIMK2, RIPK1, LRRK2, TNNI3K, TESK2, KSR2, RIPK2, MOS, MAP3K9, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain and skeletal muscle. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2RF0 (X-ray 2.00A ) |
| DBSNP | rs36102209 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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