| Gene Information | |
|---|---|
| Gene Name | MAP3K1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1512 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) |
| Target Name | mitogen-activated protein kinase kinase kinase 1 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000095015 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13233 |
| Gene Card | MAP3K1 |
| Uniprot ID | Q13233 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (1.169620185) |
| Ortholog in Animals | Alpaca_ MAP3K1 ( ortholog_one2one ) Dog_ MAP3K1 ( ortholog_one2one ) GuineaPig_ MAP3K1 ( ortholog_one2one ) Macaque_ MAP3K1 ( ortholog_one2one ) Mouse_ Map3k1 ( ortholog_one2one ) Pig_ MAP3K1 ( ortholog_one2one ) Rat_ Map3k1 ( ortholog_one2one ) Rabbit_ MAP3K1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6WHB (X-ray 1.90A ) |
| DBSNP | rs387906788 rs387906788 rs143853590 rs702689 rs832582 |
| Subcellular location [CC] | NA |
| Mouse PG classification | LPG |
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