| Gene Information | |
|---|---|
| Gene Name | TLR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 786 |
| Protein Names | Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000174125 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q15399 |
| Gene Card | TLR1 |
| Uniprot ID | Q15399 |
| Pfam | PF13855; PF01463; PF01582 |
| In ASD | no |
| Allosteric Prediction | no (-0.032294615) |
| Ortholog in Animals | Alpaca_ TLR1 ( ortholog_one2one ) Dog_ TLR1 ( ortholog_one2one ) GuineaPig_ TLR1 ( ortholog_one2one ) Macaque_ TLR1 ( ortholog_one2one ) Mouse_ Tlr1 ( ortholog_one2one ) Pig_ TLR1 ( ortholog_one2one ) Rat_ Tlr1 ( ortholog_one2one ) Rabbit_ TLR1 ( ortholog_one2one ) |
| Ohnologs | TLR2 |
| Paralogs | CD180, RXFP1, TLR8, NRROS, TLR5, TSKU, TLR7, TLR10, RXFP2, TLR6, LRRC3B, IGFALS, TLR3, TLR2, TLR4, LRRC17, LRRC32, LRRC53, VASN, LRRC3C, LRRC3, LRIT2 |
| Tissue | whole.blood |
| Tissue Specificity | Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FYV (X-ray 2.90A ) 2Z7X (X-ray 2.10A ) 6NIH (X-ray 2.30A ) 7NT7 (NMR - ) 7NUW (X-ray 1.90A ) 7NUX (X-ray 2.47A ) |
| DBSNP | rs76600635 rs137853170 rs5743611 rs5743612 rs4833095 rs3923647 rs5743613 rs76796448 rs137853171 rs137853172 rs137853173 rs5743617 rs5743618 rs5743619 rs137853174 rs113706342 rs5743621 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16880211}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9EPQ1}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. {ECO:0000269|PubMed:16880211}. |
| Mouse PG classification | NA |
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