| Gene Information | |
|---|---|
| Gene Name | MYLK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 596 |
| Protein Names | Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18) |
| Target Name | myosin light chain kinase 2, skeletal/cardiac muscle |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000101306 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H1R3 |
| Gene Card | MYLK2 |
| Uniprot ID | Q9H1R3 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.961534405) |
| Ortholog in Animals | Alpaca_ MYLK2 ( ortholog_one2one ) Dog_ MYLK2 ( ortholog_one2one ) GuineaPig_ MYLK2 ( ortholog_one2one ) Macaque_ MYLK2 ( ortholog_one2one ) Mouse_ Mylk2 ( ortholog_one2one ) Pig_ MYLK2 ( ortholog_one2one ) Rat_ Mylk2 ( ortholog_one2one ) Rabbit_ MYLK2 ( ortholog_one2one ) |
| Ohnologs | MYLK4 |
| Paralogs | DCLK3, PHKG1, MYLK4, CAMKK1, CAMKK2, DCLK2, PSKH1, PNCK, CAMK1D, CAMKV, CAMK2B, CAMK1, STK11, STK33, PHKG2, DCLK1, PSKH2, CAMK2G, CAMK2D, CAMK2A, MYLK3, CAMK1G |
| Tissue | skeletal.muscle, artery |
| Tissue Specificity | Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2LV6 (Other - ) 3KF9 (X-ray 2.60A ) |
| DBSNP | rs121908107 rs121908108 rs1229709568 rs56385445 rs34396614 rs34146416 |
| Subcellular location [CC] | Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils. |
| Mouse PG classification | NA |
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