| Gene Information | |
|---|---|
| Gene Name | CLCN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 760 |
| Protein Names | H(+)/Cl(-) exchange transporter 4 (Chloride channel protein 4) (ClC-4) (Chloride transporter ClC-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000073464 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P51793 |
| Gene Card | CLCN4 |
| Uniprot ID | P51793 |
| Pfam | PF00571; PF00654 |
| In ASD | no |
| Allosteric Prediction | no (-0.43453231) |
| Ortholog in Animals | Alpaca_ CLCN4 ( ortholog_one2one ) Dog_ CLCN4 ( ortholog_one2one ) GuineaPig_ CLCN4 ( ortholog_one2one ) Macaque_ CLCN4 ( ortholog_one2one ) Mouse_ Clcn4 ( ortholog_one2one ) Pig_ CLCN4 ( ortholog_one2one ) Rat_ Clcn4 ( ortholog_one2one ) |
| Ohnologs | CLCN3 |
| Paralogs | CLCN6, CLCN3, CLCN5, CLCNKB, CLCNKA, CLCN1, CLCN7, CLCN2 |
| Tissue | cerebral.cortex, brain, heart, testis |
| Tissue Specificity | Abundant in skeletal muscle and also detectable in brain and heart. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs879255591 rs1569226551 rs879255580 rs879255581 rs1569230006 rs879255585 rs879255582 rs1569231897 rs587777161 rs879255583 rs879255584 rs1569233549 |
| Subcellular location [CC] | Early endosome membrane {ECO:0000250|UniProtKB:P51794}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17023393, ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3. {ECO:0000269|PubMed:28972156}. |
| Mouse PG classification | NA |
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