| Gene Information | |
|---|---|
| Gene Name | RALGDS |
| Organism | Homo sapiens (Human) |
| Gene Length | 914 |
| Protein Names | Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000160271 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q12967 |
| Gene Card | RALGDS |
| Uniprot ID | Q12967 |
| Pfam | PF00788; PF00617; PF00618 |
| In ASD | no |
| Allosteric Prediction | no (-0.065831122) |
| Ortholog in Animals | Alpaca_ RALGDS ( ortholog_one2one ) Dog_ RALGDS ( ortholog_one2one ) GuineaPig_ RALGDS ( ortholog_one2one ) Macaque_ RALGDS ( ortholog_one2one ) Mouse_ Ralgds ( ortholog_one2one ) Pig_ RALGDS ( ortholog_one2one ) Rat_ Ralgds ( ortholog_one2one ) |
| Ohnologs | RGL3, RGL1 |
| Paralogs | RASGEF1A, RASGRF2, RASGRP3, SOS2, RAPGEF3, RAPGEF6, RASGRF1, RAPGEF2, RGL1, RAPGEF1, RASGEF1B, RASGRP2, RGL2, SOS1, RGL3, RALGPS1, RALGPS2, RAPGEF4, RGL4, RASGRP4, RAPGEFL1, RAPGEF5, RASGRP1, RASGEF1C |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1RAX (NMR - ) 2B3A (NMR - ) 2RGF (NMR - ) 3KH0 (X-ray 2.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q03385}. Nucleus {ECO:0000250|UniProtKB:Q03385}. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. {ECO:0000250|UniProtKB:Q03385}. |
| Mouse PG classification | NA |
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