| Gene Information | |
|---|---|
| Gene Name | PLEKHG4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1191 |
| Protein Names | Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000196155 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q58EX7 |
| Gene Card | PLEKHG4 |
| Uniprot ID | Q58EX7 |
| Pfam | PF00621 |
| In ASD | no |
| Allosteric Prediction | no (-1.099214601) |
| Ortholog in Animals | Alpaca_ PLEKHG4 ( ortholog_one2one ) Dog_ PLEKHG4 ( ortholog_one2one ) GuineaPig_ PLEKHG4 ( ortholog_one2one ) Mouse_ Plekhg4 ( ortholog_one2one ) Pig_ PLEKHG4 ( ortholog_one2one ) Rat_ Plekhg4 ( ortholog_one2one ) Rabbit_ PLEKHG4 ( ortholog_one2one ) |
| Ohnologs | PLEKHG4B, ARHGEF40 |
| Paralogs | MCF2L2, VAV1, PLEKHN1, TIAM2, ARHGEF40, ARHGEF25, VAV2, VAV3, SPATA13, ARHGEF9, ARHGEF6, PLEKHG1, SESTD1, PLEKHG2, KIAA1755, PLEKHG4B, TIAM1, MCF2, KALRN, ARHGEF7, MCF2L, TRIO |
| Tissue | NA |
| Tissue Specificity | Expressed in kidney, Leydig cells in the testis, epithelial cells in the prostate gland and Langerhans islet in the pancreas. Isoform 1 and isoform 3 are strongly expressed in Purkinje cells and to a lower extent in other neurons (at protein level). Widely expressed at low levels. More strongly expressed in testis and pancreas. {ECO:0000269|PubMed:16001362}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11860295 rs8044843 rs3868142 rs56077142 rs17680862 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
| click here to return to the previous page | |