| Gene Information | |
|---|---|
| Gene Name | DOK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 412 |
| Protein Names | Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000147443 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O60496 |
| Gene Card | DOK2 |
| Uniprot ID | O60496 |
| Pfam | PF02174 |
| In ASD | no |
| Allosteric Prediction | no (-0.242013718) |
| Ortholog in Animals | Alpaca_ DOK2 ( ortholog_one2one ) Dog_ DOK2 ( ortholog_one2one ) GuineaPig_ DOK2 ( ortholog_one2one ) Macaque_ DOK2 ( ortholog_one2one ) Mouse_ Dok2 ( ortholog_one2one ) Pig_ DOK2 ( ortholog_one2one ) Rat_ Dok2 ( ortholog_one2one ) |
| Ohnologs | DOK1, DOK3 |
| Paralogs | DOK6, DOK4, FRS3, FRS2, DOK1, DOK3, DOK5 |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. {ECO:0000269|PubMed:9478921}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.014286(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2D9W (NMR - ) 2DLW (NMR - ) |
| DBSNP | rs1140295 rs34215892 rs2242241 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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