| Gene Information | |
|---|---|
| Gene Name | GNAT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 354 |
| Protein Names | Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000134183 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P19087 |
| Gene Card | GNAT2 |
| Uniprot ID | P19087 |
| Pfam | PF00503 |
| In ASD | no |
| Allosteric Prediction | no (-0.047068897) |
| Ortholog in Animals | Alpaca_ GNAT2 ( ortholog_one2one ) Dog_ GNAT2 ( ortholog_one2one ) Macaque_ GNAT2 ( ortholog_one2one ) Mouse_ Gnat2 ( ortholog_one2one ) Pig_ GNAT2 ( ortholog_one2one ) Rat_ Gnat2 ( ortholog_one2one ) Rabbit_ GNAT2 ( ortholog_one2one ) |
| Ohnologs | GNAT1 |
| Paralogs | GNAZ, GNAT1, GNAL, GNA13, GNA12, GNAI2, GNAO1, GNAI3, GNAI1, GNA15, GNA11, GNAT3, GNAS, GNA14, GNAQ |
| Tissue | NA |
| Tissue Specificity | Retinal rod outer segment. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002590(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6N84 (X-ray 1.75A ) 6N85 (X-ray 2.50A ) |
| DBSNP | rs3738766 rs41280330 rs1799940 |
| Subcellular location [CC] | Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P50149}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P50149}. Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. {ECO:0000250|UniProtKB:P50149}. |
| Mouse PG classification | HPG |
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