| Gene Information | |
|---|---|
| Gene Name | GNAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) |
| Target Name | guanine nucleotide-binding protein g(t) subunit alpha-1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000114349 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P11488 |
| Gene Card | GNAT1 |
| Uniprot ID | P11488 |
| Pfam | PF00503 |
| In ASD | no |
| Allosteric Prediction | yes (0.677153728) |
| Ortholog in Animals | Alpaca_ GNAT1 ( ortholog_one2one ) Dog_ GNAT1 ( ortholog_one2one ) GuineaPig_ GNAT1 ( ortholog_one2one ) Macaque_ GNAT1 ( ortholog_one2one ) Mouse_ Gnat1 ( ortholog_one2one ) Pig_ GNAT1 ( ortholog_one2one ) Rat_ Gnat1 ( ortholog_one2one ) |
| Ohnologs | GNAT3, GNAT2 |
| Paralogs | GNAZ, GNAL, GNA13, GNA12, GNAI2, GNAT2, GNAO1, GNAI3, GNAI1, GNA15, GNA11, GNAT3, GNAS, GNA14, GNAQ |
| Tissue | NA |
| Tissue Specificity | Rod photoreceptor cells (PubMed:1614872). Predominantly expressed in the retina followed by the ciliary body, iris and retinal pigment epithelium (PubMed:22190596). {ECO:0000269|PubMed:1614872, ECO:0000269|PubMed:22190596}. |
| Pharmacological Animal Models | 0.023929(Chimpanzee);0.085723(Mouse);0.002590(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3RBQ (X-ray 2.00A ) |
| DBSNP | rs104893740 rs786205854 rs786205853 |
| Subcellular location [CC] | Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P04695}. Membrane {ECO:0000250|UniProtKB:P04695}; Peripheral membrane protein {ECO:0000250|UniProtKB:P04695}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P20612}. Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. {ECO:0000250|UniProtKB:P20612}. |
| Mouse PG classification | NA |
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