| Gene Information | |
|---|---|
| Gene Name | ICOSLG |
| Organism | Homo sapiens (Human) |
| Gene Length | 302 |
| Protein Names | ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275) |
| Target Name | b7-related protein 1 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000160223 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75144 |
| Gene Card | ICOSLG |
| Uniprot ID | O75144 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.814051928) |
| Ortholog in Animals | Dog_ ICOSLG ( ortholog_one2one ) Macaque_ ICOSLG ( ortholog_one2one ) Mouse_ Icosl ( ortholog_one2one ) Rat_ Icoslg ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BTN2A2, CD276, BTNL2, BTN2A1, BTNL9, ERMAP, HHLA2, VTCN1, BTN1A1, BTN3A3, BTN3A2, BTN3A1, MOG, BTNL3, BTNL8 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. {ECO:0000269|PubMed:10779774}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6X4G (X-ray 3.50A ) 6X4T (X-ray 3.15A ) |
| DBSNP | rs11558819 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11007762}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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