| Gene Information | |
|---|---|
| Gene Name | GNAI3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 354 |
| Protein Names | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000065135 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P08754 |
| Gene Card | GNAI3 |
| Uniprot ID | P08754 |
| Pfam | PF00503 |
| In ASD | yes |
| Allosteric Prediction | yes (1.666021371) |
| Ortholog in Animals | Alpaca_ GNAI3 ( ortholog_one2one ) Dog_ GNAI3 ( ortholog_one2one ) GuineaPig_ GNAI3 ( ortholog_one2one ) Macaque_ GNAI3 ( ortholog_one2one ) Mouse_ Gnai3 ( ortholog_one2one ) Pig_ GNAI3 ( ortholog_one2one ) Rat_ Gnai3 ( ortholog_one2one ) Rabbit_ GNAI3 ( ortholog_one2one ) |
| Ohnologs | GNAI2, GNAI1 |
| Paralogs | GNAZ, GNAT1, GNAL, GNA13, GNA12, GNAI2, GNAT2, GNAO1, GNA15, GNA11, GNAT3, GNAS, GNA14, GNAQ, GNAI1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001490(Rat);0.167933(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2IHB (X-ray 2.71A ) 2ODE (X-ray 1.90A ) 2V4Z (X-ray 2.80A ) 4G5O (X-ray 2.90A ) 4G5R (X-ray 3.48A ) 4G5S (X-ray 3.62A ) 7E9H (EM 4.00A ) 7KH0 (EM 2.80A ) 7RA3 (EM 3.24A ) 7RGP (EM 2.90A ) 7T10 (EM 2.50A ) 7T11 (EM 2.70A ) |
| DBSNP | rs387907178 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:27864364}; Lipid-anchor {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. {ECO:0000269|PubMed:17635935}. |
| Mouse PG classification | LPG |
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