| Gene Information | |
|---|---|
| Gene Name | GBP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 592 |
| Protein Names | Guanylate-binding protein 1 (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000117228 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P32455 |
| Gene Card | GBP1 |
| Uniprot ID | P32455 |
| Pfam | PF02263; PF02841 |
| In ASD | yes |
| Allosteric Prediction | yes (0.613229017) |
| Ortholog in Animals | Alpaca_ GBP1 ( ortholog_one2one ) Dog_ GBP1 ( ortholog_one2one ) GuineaPig_ GBP1 ( ortholog_one2one ) Pig_ GBP1 ( ortholog_one2one ) Rat_ Gbp1 ( ortholog_one2many ) Rabbit_ GBP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATL1, GBP5, ATL2, GBP7, ATL3, GBP2, GBP6, RNF112, GBP4, GBP3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DG3 (X-ray 1.80A ) 1F5N (X-ray 1.70A ) 2B8W (X-ray 2.22A ) 2B92 (X-ray 3.20A ) 2BC9 (X-ray 2.80A ) 2D4H (X-ray 2.90A ) 6K1Z (X-ray 2.31A ) 6K2D (X-ray 3.60A ) 6LOJ (X-ray 3.72A ) |
| DBSNP | rs1048401 rs17130717 rs1048425 rs1048443 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane; Lipid-anchor {ECO:0000269|PubMed:21151871}; Cytoplasmic side. Cell membrane {ECO:0000269|PubMed:21151871}. Secreted {ECO:0000269|PubMed:16936281}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q01514}. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor. |
| Mouse PG classification | NA |
| click here to return to the previous page | |