| Gene Information | |
|---|---|
| Gene Name | GLUR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 906 |
| Protein Names | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P42261 |
| Gene Card | GRIA1 |
| Uniprot ID | P42261 |
| Pfam | PF01094; PF00060; PF10613 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed in brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6X5Q (X-ray 2.14A ) |
| DBSNP | rs13166146 rs13166161 rs13166438 rs13186241 rs13186534 rs587776937 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Postsynaptic cell membrane {ECO:0000269|PubMed:23739980}; Multi-pass membrane protein {ECO:0000269|PubMed:23739980}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P23818}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23818}. Cell projection, dendrite {ECO:0000250|UniProtKB:P23818}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P23818}. Early endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Recycling endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Presynapse {ECO:0000250|UniProtKB:P23818}. Synapse {ECO:0000250|UniProtKB:P23818}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000250|UniProtKB:P23818}. |
| Mouse PG classification | NA |
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