| Gene Information | |
|---|---|
| Gene Name | GLUL |
| Organism | Homo sapiens (Human) |
| Gene Length | 373 |
| Protein Names | Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) |
| Target Name | glutamate decarboxylase |
| Target Type | Discontinued target |
| Gene Age | 645 ( ENSG00000135821 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P15104 |
| Gene Card | GLUL |
| Uniprot ID | P15104 |
| Pfam | PF00120; PF03951 |
| In ASD | no |
| Allosteric Prediction | yes (0.936640382) |
| Ortholog in Animals | Alpaca_ GLUL ( ortholog_one2one ) Dog_ GLUL ( ortholog_one2one ) GuineaPig_ GLUL ( ortholog_one2one ) Macaque_ GLUL ( ortholog_one2one ) Mouse_ Glul ( ortholog_one2one ) Rat_ Glul ( ortholog_one2one ) Rabbit_ GLUL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LGSN |
| Tissue | NA |
| Tissue Specificity | Expressed in endothelial cells. {ECO:0000269|PubMed:30158707}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2OJW (X-ray 2.05A ) 2QC8 (X-ray 2.60A ) 7EVT (X-ray 2.95A ) |
| DBSNP | rs80358214 rs80358215 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:30158707}. Microsome {ECO:0000250|UniProtKB:P09606}. Mitochondrion {ECO:0000250|UniProtKB:P09606}. Cell membrane {ECO:0000269|PubMed:30158707}; Lipid-anchor {ECO:0000269|PubMed:30158707}. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane. {ECO:0000269|PubMed:30158707}. |
| Mouse PG classification | LPG |
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