Gene Information
Gene NameNOTCH2
OrganismHomo sapiens (Human)
Gene Length2471
Protein NamesNeurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Target Namenotch-2 receptor
Target TypeClinical trial target
Gene Age645 ( ENSG00000134250 )
Evolutionary StageEukaryota
AlphaFoldDBQ04721
Gene CardNOTCH2
Uniprot IDQ04721
PfamPF12796; PF00008; PF07645; PF12661; PF06816; PF07684; PF00066
In ASDno
Allosteric Predictionyes (0.05255115)
Ortholog in AnimalsAlpaca_ NOTCH2 ( ortholog_one2one )
Dog_ NOTCH2 ( ortholog_one2one )
GuineaPig_ NOTCH2 ( ortholog_one2one )
Macaque_ NOTCH2 ( ortholog_one2one )
Mouse_ Notch2 ( ortholog_one2one )
Pig_ NOTCH2 ( ortholog_one2one )
Rat_ Notch2 ( ortholog_one2one )
Rabbit_ NOTCH2 ( ortholog_one2one )
OhnologsNOTCH3
ParalogsNOTCH3, SNED1, NOTCH1, NOTCH2NLA, NOTCH2NLC, NOTCH2NLB, NOTCH2NLR
TissueNA
Tissue SpecificityExpressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo. {ECO:0000269|PubMed:21378985}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2OO4  (X-ray  2.00A  )  5MWB  (X-ray  1.86A  ) 
DBSNP rs111033632  rs17024517 
Subcellular location [CC][Notch 2 extracellular truncation]: Cell membrane {ECO:0000269|PubMed:29329397, ECO:0000269|PubMed:9244302};
Single-pass type I membrane protein {ECO:0000269|PubMed:9244302}.;
[Notch 2 intracellular domain]: Nucleus {ECO:0000269|PubMed:25985737}. Cytoplasm {ECO:0000269|PubMed:25985737}. Note=Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM (PubMed:25985737). {ECO:0000269|PubMed:25985737}.
Mouse PG classificationNA
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