| Gene Information | |
|---|---|
| Gene Name | GLT |
| Organism | Homo sapiens (Human) |
| Gene Length | 478 |
| Protein Names | Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NZM5 |
| Gene Card | NOP53 |
| Uniprot ID | Q9NZM5 |
| Pfam | PF07767 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung. {ECO:0000269|PubMed:10708517}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002043(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1042401 rs1804994 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:10196275, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20042497, ECO:0000269|PubMed:22292050, ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24923447, ECO:0000269|PubMed:25956029, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27829214}. Nucleus, nucleoplasm {ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24923447, ECO:0000269|PubMed:26903295, ECO:0000269|PubMed:27323397}. Note=In the nucleolus may be more specifically localized to the fibrillar center (PubMed:27729611). Mainly nucleolar it relocalizes to the nucleoplasm under specific conditions including ribosomal stress enabling it to interact and regulate nucleoplasmic proteins like p53/TP53 (PubMed:22522597, PubMed:24923447, PubMed:27323397, PubMed:26903295). Also detected in the cytosol (PubMed:24923447, PubMed:27824081). {ECO:0000269|PubMed:22522597, ECO:0000269|PubMed:24923447, ECO:0000269|PubMed:26903295, ECO:0000269|PubMed:27323397, ECO:0000269|PubMed:27729611, ECO:0000269|PubMed:27824081}. |
| Mouse PG classification | NA |
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