| Gene Information | |
|---|---|
| Gene Name | GLS |
| Organism | Homo sapiens (Human) |
| Gene Length | 669 |
| Protein Names | Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain] |
| Target Name | glutaminase kidney isoform, mitochondrial |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000115419 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O94925 |
| Gene Card | GLS |
| Uniprot ID | O94925 |
| Pfam | PF12796; PF17959; PF04960 |
| In ASD | yes |
| Allosteric Prediction | yes (1.113491323) |
| Ortholog in Animals | Alpaca_ GLS ( ortholog_one2one ) Dog_ GLS ( ortholog_one2one ) GuineaPig_ GLS ( ortholog_one2one ) Macaque_ GLS ( ortholog_one2one ) Mouse_ Gls ( ortholog_one2one ) Pig_ GLS ( ortholog_one2one ) Rat_ Gls ( ortholog_one2one ) Rabbit_ GLS ( ortholog_one2one ) |
| Ohnologs | GLS2 |
| Paralogs | GLS2 |
| Tissue | kidney |
| Tissue Specificity | Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle. {ECO:0000269|PubMed:11015561}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3CZD (X-ray 2.40A ) 3UNW (X-ray 2.56A ) 3UO9 (X-ray 2.30A ) 3VOY (X-ray 2.20A ) 3VOZ (X-ray 2.40A ) 3VP0 (X-ray 2.40A ) 3VP1 (X-ray 2.30A ) 3VP2 (X-ray 2.70A ) 3VP3 (X-ray 2.70A ) 3VP4 (X-ray 2.45A ) 4O7D (X-ray 2.30A ) 5D3O (X-ray 2.79A ) 5FI2 (X-ray 2.50A ) 5FI6 (X-ray 2.52A ) 5FI7 (X-ray 2.50A ) 5HL1 (X-ray 2.40A ) 5I94 (X-ray 2.98A ) 5JYO (X-ray 2.10A ) 5JYP (X-ray 2.74A ) 5U0I (X-ray 1.42A ) 5U0J (X-ray 1.72A ) 5UQE (X-ray 3.60A ) 5WJ6 (X-ray 2.44A ) 6LOX (X-ray 3.20A ) 6UJG (X-ray 3.00A ) 6UJM (X-ray 2.50A ) 6UK6 (X-ray 2.90A ) 6UKB (X-ray 3.00A ) 6UL9 (X-ray 2.50A ) 6ULA (X-ray 2.95A ) 6ULJ (X-ray 2.69A ) 6UMC (X-ray 2.75A ) 6UMD (X-ray 2.70A ) 6UME (X-ray 2.90A ) 6UMF (X-ray 2.68A ) 7REN (X-ray 2.80A ) 7RGG (X-ray 3.00A ) 7SBM (X-ray 2.80A ) 7SBN (X-ray 2.14A ) |
| DBSNP | rs16833035 rs1558972120 rs1558973667 rs1558986214 |
| Subcellular location [CC] | [Isoform 1]: Mitochondrion {ECO:0000250|UniProtKB:P13264}. Cytoplasm, cytosol {ECO:0000269|PubMed:22228304}. Note=The 74-kDa cytosolic precursor is translocated into the mitochondria and processed via a 72-kDa intermediate to yield the mature 68- and 65-kDa subunits. {ECO:0000250|UniProtKB:P13264}.; [Isoform 3]: Mitochondrion {ECO:0000269|PubMed:22228304}.; [Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix {ECO:0000250|UniProtKB:P13264}. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. {ECO:0000250|UniProtKB:P13264}.; [Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix {ECO:0000250|UniProtKB:P13264}. Note=Produced by the proteolytic processing of the 74-kDa cytosolic precursor. {ECO:0000250|UniProtKB:P13264}. |
| Mouse PG classification | NA |
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