| Gene Information | |
|---|---|
| Gene Name | GLRB |
| Organism | Homo sapiens (Human) |
| Gene Length | 497 |
| Protein Names | Glycine receptor subunit beta (Glycine receptor 58 kDa subunit) |
| Target Name | glycine receptors |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000109738 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P48167 |
| Gene Card | GLRB |
| Uniprot ID | P48167 |
| Pfam | PF02931; PF02932 |
| In ASD | yes |
| Allosteric Prediction | yes (0.99968607) |
| Ortholog in Animals | Alpaca_ GLRB ( ortholog_one2one ) Dog_ GLRB ( ortholog_one2one ) GuineaPig_ GLRB ( ortholog_one2one ) Macaque_ GLRB ( ortholog_one2one ) Mouse_ Glrb ( ortholog_one2one ) Pig_ GLRB ( ortholog_one2one ) Rat_ Glrb ( ortholog_one2one ) Rabbit_ GLRB ( ortholog_one2one ) |
| Ohnologs | GABRA3, GABRP, GLRA2, GABRA6, GLRA1, GLRA4 |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1 |
| Tissue | cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5BKF (EM 3.60A ) 5BKG (EM 3.80A ) 7KUY (EM 3.60A ) 7L31 (EM 3.80A ) |
| DBSNP | rs398122856 rs121909749 |
| Subcellular location [CC] | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P48168}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000250|UniProtKB:P48168}. Cell projection, dendrite {ECO:0000250|UniProtKB:P48168}. Cell membrane {ECO:0000269|PubMed:11929858, ECO:0000269|PubMed:12684523, ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:22973015, ECO:0000269|PubMed:23238346, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:8717357}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cytoplasm {ECO:0000269|PubMed:12684523}. Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523). Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. {ECO:0000250|UniProtKB:P20781, ECO:0000269|PubMed:12684523}. |
| Mouse PG classification | NA |
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