Gene Information
Gene NamePLA2G4C
OrganismHomo sapiens (Human)
Gene Length541
Protein NamesCytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000105499 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ9UP65
Gene CardPLA2G4C
Uniprot IDQ9UP65
PfamPF01735
In ASDno
Allosteric Predictionyes (0.322623311)
Ortholog in AnimalsAlpaca_ PLA2G4C ( ortholog_one2one )
Macaque_ PLA2G4C ( ortholog_one2one )
Mouse_ Pla2g4c ( ortholog_one2one )
Rat_ Pla2g4c ( ortholog_one2one )
OhnologsPLA2G4D, PLA2G4F, JMJD7-PLA2G4B, PLA2G4E
ParalogsPLA2G4B, PLA2G4D, PLA2G4A, PLA2G4F, PLA2G4E
TissueNA
Tissue SpecificityHighly expressed in heart and skeletal muscle. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:9705332}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs11564522  rs2307279  rs11564532  rs11564534  rs2303744  rs2307282  rs11564538  rs156631  rs11564541  rs11564620  rs11564638  rs191276960 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:14529291, ECO:0000269|PubMed:9705332};
Lipid-anchor {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:14529291, ECO:0000269|PubMed:9705332}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189, ECO:0000269|PubMed:28336330};
Lipid-anchor. Mitochondrion membrane {ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189};
Lipid-anchor. Lipid droplet {ECO:0000269|PubMed:28336330}. Note=Translocates from endoplasmic reticulum to lipid droplets in response to oleate. {ECO:0000269|PubMed:28336330}.
Mouse PG classificationNA
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