| Gene Information | |
|---|---|
| Gene Name | PGY1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1280 |
| Protein Names | ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P08183 |
| Gene Card | ABCB1 |
| Uniprot ID | P08183 |
| Pfam | PF00664; PF00005 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in small intestine (PubMed:28408210). Expressed in liver, kidney and brain. {ECO:0000269|PubMed:28408210}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6C0V (EM 3.40A ) 6FN1 (EM 3.58A ) 6FN4 (EM 4.14A ) 6QEX (EM 3.60A ) 7A65 (EM 3.90A ) 7A69 (EM 3.20A ) 7A6C (EM 3.60A ) 7A6E (EM 3.60A ) 7A6F (EM 3.50A ) 7O9W (EM 3.50A ) |
| DBSNP | rs28381804 rs9282564 rs1202183 rs9282565 rs1128501 rs36008564 rs2229109 rs28381902 rs28381914 rs2235036 rs35023033 rs2235039 rs2032581 rs28381967 rs2032582 rs2032582 rs926081975 rs72552784 rs28401798 rs55852620 rs2229107 rs28364274 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:35970996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:8898203}. Cytoplasm {ECO:0000269|PubMed:35970996}. Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). {ECO:0000269|PubMed:35970996}. |
| Mouse PG classification | NA |
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