| Gene Information | |
|---|---|
| Gene Name | SSX2IP |
| Organism | Homo sapiens (Human) |
| Gene Length | 614 |
| Protein Names | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000117155 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y2D8 |
| Gene Card | SSX2IP |
| Uniprot ID | Q9Y2D8 |
| Pfam | PF11559 |
| In ASD | no |
| Allosteric Prediction | no (-1.384040944) |
| Ortholog in Animals | Alpaca_ SSX2IP ( ortholog_one2one ) Dog_ SSX2IP ( ortholog_one2one ) GuineaPig_ SSX2IP ( ortholog_one2one ) Macaque_ SSX2IP ( ortholog_one2one ) Mouse_ Ssx2ip ( ortholog_one2one ) Pig_ SSX2IP ( ortholog_one2one ) Rat_ Ssx2ip ( ortholog_one2one ) Rabbit_ SSX2IP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1057746 |
| Subcellular location [CC] | Cell junction, adherens junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:23816619, ECO:0000269|PubMed:24356449}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24356449}. Note=Not found at cell-matrix AJs. {ECO:0000250}. |
| Mouse PG classification | NA |
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