| Gene Information | |
|---|---|
| Gene Name | GLI3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1580 |
| Protein Names | Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000106571 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P10071 |
| Gene Card | GLI3 |
| Uniprot ID | P10071 |
| Pfam | PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-0.152112928) |
| Ortholog in Animals | Alpaca_ GLI3 ( ortholog_one2one ) Dog_ GLI3 ( ortholog_one2one ) GuineaPig_ GLI3 ( ortholog_one2one ) Macaque_ GLI3 ( ortholog_one2one ) Mouse_ Gli3 ( ortholog_one2one ) Pig_ GLI3 ( ortholog_one2one ) Rat_ Gli3 ( ortholog_one2one ) Rabbit_ GLI3 ( ortholog_one2one ) |
| Ohnologs | GLI1, GLI2 |
| Paralogs | AEBP2, GLIS3, GLI2, ZXDC, GLIS2, GLIS1, ZXDA, ZXDB, ZIC4, ZIC5, ZIC3, ZIC2, GLI1, ZIC1 |
| Tissue | NA |
| Tissue Specificity | Is expressed in a wide variety of normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4BLD (X-ray 2.80A ) |
| DBSNP | rs1419861206 rs846266 rs121917712 rs121917716 rs121917710 rs62622373 rs28933372 rs929387 rs1277170270 rs35280470 rs35364414 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Cell projection, cilium. Note=GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO. Translocation to the nucleus is promoted by interaction with ZIC1. |
| Mouse PG classification | HPG |
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