| Gene Information | |
|---|---|
| Gene Name | GLI2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1586 |
| Protein Names | Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000074047 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P10070 |
| Gene Card | GLI2 |
| Uniprot ID | P10070 |
| Pfam | PF00096 |
| In ASD | no |
| Allosteric Prediction | yes (0.424504786) |
| Ortholog in Animals | Alpaca_ GLI2 ( ortholog_one2one ) Dog_ GLI2 ( ortholog_one2one ) GuineaPig_ GLI2 ( ortholog_one2one ) Macaque_ GLI2 ( ortholog_one2one ) Mouse_ Gli2 ( ortholog_one2one ) Pig_ GLI2 ( ortholog_one2one ) Rabbit_ GLI2 ( ortholog_one2one ) |
| Ohnologs | GLI3, GLI1 |
| Paralogs | AEBP2, GLIS3, ZXDC, GLIS2, GLIS1, ZXDA, ZXDB, ZIC4, ZIC5, ZIC3, ZIC2, GLI1, GLI3, ZIC1 |
| Tissue | ovary |
| Tissue Specificity | Expressed in breast cancers (at protein level) (PubMed:26565916). Isoform 1 and isoform 4 are expressed in HTLV-1-infected T-cell lines (at protein level) (PubMed:9557682). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines (PubMed:9557682). Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines (PubMed:9557682). {ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs13427953 rs121917708 rs12618388 rs149800897 rs3099537 rs1272759660 rs3738880 rs12711538 rs149140724 rs146467786 rs114814747 rs138987487 rs767802807 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:26565916}. Cytoplasm {ECO:0000250|UniProtKB:Q0VGT2}. Cell projection, cilium {ECO:0000250|UniProtKB:Q0VGT2}. Note=STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus. {ECO:0000250|UniProtKB:Q0VGT2}.; [Isoform 1]: Nucleus {ECO:0000269|PubMed:9557682}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:9557682}. |
| Mouse PG classification | HPG |
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