| Gene Information | |
|---|---|
| Gene Name | GLI1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1106 |
| Protein Names | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) |
| Target Name | zinc finger protein gli1 |
| Target Type | Patented-recorded target |
| Gene Age | 544 ( ENSG00000111087 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P08151 |
| Gene Card | GLI1 |
| Uniprot ID | P08151 |
| Pfam | PF00096 |
| In ASD | no |
| Allosteric Prediction | yes (0.536554919) |
| Ortholog in Animals | Alpaca_ GLI1 ( ortholog_one2one ) Dog_ GLI1 ( ortholog_one2one ) GuineaPig_ GLI1 ( ortholog_one2one ) Macaque_ GLI1 ( ortholog_one2one ) Mouse_ Gli1 ( ortholog_one2one ) Pig_ GLI1 ( ortholog_one2one ) Rat_ Gli1 ( ortholog_one2one ) Rabbit_ GLI1 ( ortholog_one2one ) |
| Ohnologs | GLI2, GLI3, GLIS3 |
| Paralogs | AEBP2, GLIS3, GLI2, ZXDC, GLIS2, GLIS1, ZXDA, ZXDB, ZIC4, ZIC5, ZIC3, ZIC2, GLI3, ZIC1 |
| Tissue | tibial.nerve |
| Tissue Specificity | Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761). {ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.026667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2GLI (X-ray 2.60A ) 4BLB (X-ray 2.80A ) 4KMD (X-ray 1.70A ) 5OM0 (X-ray 3.20A ) |
| DBSNP | rs753690500 rs2228224 rs2229300 rs2228226 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24076122}. Nucleus {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456}. Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19878745}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19706761}. Nucleus {ECO:0000269|PubMed:19706761}. |
| Mouse PG classification | NA |
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