| Gene Information | |
|---|---|
| Gene Name | GLE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 698 |
| Protein Names | mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000119392 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q53GS7 |
| Gene Card | GLE1 |
| Uniprot ID | Q53GS7 |
| Pfam | PF07817 |
| In ASD | no |
| Allosteric Prediction | no (-0.829258454) |
| Ortholog in Animals | Alpaca_ GLE1 ( ortholog_one2one ) Dog_ GLE1 ( ortholog_one2one ) GuineaPig_ GLE1 ( ortholog_one2one ) Macaque_ GLE1 ( ortholog_one2one ) Mouse_ Gle1 ( ortholog_one2one ) Pig_ GLE1 ( ortholog_one2one ) Rat_ Gle1 ( ortholog_one2many ) Rat_ AABR07065139.1 ( ortholog_one2many ) Rat_ AABR07065139.2 ( ortholog_one2many ) Rabbit_ GLE1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001490(Rat);0.042857(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6B4F (X-ray 2.81A ) 6B4I (X-ray 3.62A ) 6B4J (X-ray 3.40A ) |
| DBSNP | rs17852725 rs2275260 rs121434407 rs17856852 rs121434408 rs121434409 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12668658}. Cytoplasm {ECO:0000269|PubMed:12668658}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658). {ECO:0000269|PubMed:12668658}.; [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:12668658}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:12668658}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:12668658). In the nucleus, isoform 1 localizes to the nuclear pore complex and nuclear envelope (PubMed:12668658). Shuttling is essential for its mRNA export function (PubMed:12668658). {ECO:0000269|PubMed:12668658}. |
| Mouse PG classification | NA |
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