| Gene Information | |
|---|---|
| Gene Name | GLA |
| Organism | Homo sapiens (Human) |
| Gene Length | 227 |
| Protein Names | N-acetyltransferase 8 (EC 2.3.1.-) (Acetyltransferase 2) (ATase2) (Camello-like protein 1) (Cysteinyl-conjugate N-acetyltransferase) (CCNAT) (EC 2.3.1.80) |
| Target Name | alpha-galactosidase a |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000102393 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UHE5 |
| Gene Card | NAT8 |
| Uniprot ID | Q9UHE5 |
| Pfam | PF00583 |
| In ASD | no |
| Allosteric Prediction | yes (0.477597555) |
| Ortholog in Animals | Alpaca_ GLA ( ortholog_one2one ) Alpaca_ GLA ( ortholog_one2many ) Dog_ GLA ( ortholog_one2one ) GuineaPig_ GLA ( ortholog_one2one ) Macaque_ GLA ( ortholog_one2one ) Mouse_ Gla ( ortholog_one2one ) Pig_ GLA ( ortholog_one2one ) Rat_ Gla ( ortholog_one2one ) |
| Ohnologs | NAGA |
| Paralogs | NAGA |
| Tissue | NA |
| Tissue Specificity | Preferentially expressed in liver and kidney. Also detected in brain (at protein level). {ECO:0000269|PubMed:22267734, ECO:0000269|PubMed:9852678}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs13424561 rs13538 |
| Subcellular location [CC] | Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. |
| Mouse PG classification | NA |
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