Gene Information

Gene Information
Gene Name	GLA
Organism	Homo sapiens (Human)
Gene Length	429
Protein Names	Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Galactosylgalactosylglucosylceramidase GLA) (Melibiase) (Agalsidase)
Target Name	alpha-galactosidase a
Target Type	Successful target
Gene Age	680 ( ENSG00000102393 )
Evolutionary Stage	Euk+Bac
AlphaFoldDB	P06280
Gene Card	GLA
Uniprot ID	P06280
Pfam	PF16499; PF17450
In ASD	no
Allosteric Prediction	yes (0.477597555)
Ortholog in Animals	Alpaca_ GLA ( ortholog_one2one ) Alpaca_ GLA ( ortholog_one2many ) Dog_ GLA ( ortholog_one2one ) GuineaPig_ GLA ( ortholog_one2one ) Macaque_ GLA ( ortholog_one2one ) Mouse_ Gla ( ortholog_one2one ) Pig_ GLA ( ortholog_one2one ) Rat_ Gla ( ortholog_one2one )
Ohnologs	NAGA
Paralogs	NAGA
Tissue	NA
Tissue Specificity	NA
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1R46 (X-ray 3.25A ) 1R47 (X-ray 3.45A ) 3GXN (X-ray 3.01A ) 3GXP (X-ray 2.20A ) 3GXT (X-ray 2.70A ) 3HG2 (X-ray 2.30A ) 3HG3 (X-ray 1.90A ) 3HG4 (X-ray 2.30A ) 3HG5 (X-ray 2.30A ) 3LX9 (X-ray 2.04A ) 3LXA (X-ray 3.04A ) 3LXB (X-ray 2.85A ) 3LXC (X-ray 2.35A ) 3S5Y (X-ray 2.10A ) 3S5Z (X-ray 2.00A ) 3TV8 (X-ray 2.64A ) 4NXS (X-ray 2.55A ) 6IBK (X-ray 1.99A ) 6IBM (X-ray 2.07A ) 6IBR (X-ray 2.02A ) 6IBT (X-ray 2.04A )
DBSNP	rs150547672 rs869312133 rs869312134 rs104894847 rs869312135 rs869312448 rs1569306168 rs869312136 rs104894835 rs869312137 rs869312138 rs398123199 rs104894831 rs797044613 rs398123201 rs797044613 rs398123203 rs1928582757 rs869312254 rs398123205 rs1057521047 rs869312256 rs869312258 rs104894836 rs869312258 rs869312262 rs869312139 rs104894848 rs104894833 rs781927744 rs781838005 rs1569304898 rs869312140 rs1569304886 rs869312141 rs869312141 rs886041315 rs869312270 rs113173389 rs1569304867 rs869312273 rs104894834 rs372966991 rs869312142 rs869312142 rs782197638 rs869312298 rs1569304221 rs1928326524 rs886044845 rs104894845 rs104894845 rs104894837 rs1555985829 rs1569304190 rs869312143 rs28935195 rs869312307 rs869312311 rs28935196 rs869312144 rs869312318 rs869312145 rs869312320 rs869312146 rs869312340 rs869312147 rs727503950 rs104894838 rs869312344 rs869312148 rs397515870 rs869312149 rs869312150 rs28935197 rs1928199003 rs869312151 rs869312381 rs1555985175 rs869312383 rs1928196393 rs104894840 rs104894840 rs869312152 rs1928195468 rs797044746 rs869312386 rs397515873 rs397515874 rs727503948 rs727503948 rs869312393 rs727505292 rs869312153 rs869312399 rs869312399 rs869312154 rs869312404 rs28935486 rs190347120 rs869312407 rs28935487 rs730880451 rs28935488 rs28935488 rs28935495 rs869312432 rs28935485 rs1928171557 rs104894839 rs869312437 rs140329381 rs140329381 rs104894846 rs104894830 rs28935489 rs1569302985 rs104894828 rs869312155 rs28935490 rs28935490 rs869312156 rs869312157 rs869312158 rs730880439 rs869312159 rs28935491 rs869312160 rs869312160 rs28935492 rs104894832 rs869312161 rs1555984869 rs869312214 rs28935493 rs869312162 rs869312163 rs869312163 rs104894827 rs869312224 rs797044774 rs730880453 rs782598150 rs28935494 rs111422676 rs869312227 rs727504348 rs869312164 rs1057519609 rs869312165 rs782449839 rs878853698 rs104894852 rs869312246
Subcellular location [CC]	Lysosome.
Mouse PG classification	NA
click here to return to the previous page