Gene Information
Gene NamePTPRN2
OrganismHomo sapiens (Human)
Gene Length1015
Protein NamesReceptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]
Target NameNA
Target TypeNA
Gene Age886 ( ENSG00000155093 )
3 ( ENSG00000282185 )
Evolutionary StageMammalia
AlphaFoldDBQ92932
Gene CardPTPRN2
Uniprot IDQ92932
PfamPF11548; PF14948; PF00102
In ASDno
Allosteric Predictionno (-0.466856961)
Ortholog in AnimalsMacaque_ PTPRN2 ( ortholog_one2one )
Mouse_ Ptprn2 ( ortholog_one2one )
Pig_ PTPRN2 ( ortholog_one2one )
Rat_ Ptprn2 ( ortholog_one2one )
OhnologsPTPRN
ParalogsPTPRN, PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRH, PTPN21
TissueNA
Tissue SpecificityHighest levels in brain and pancreas (PubMed:8954911, PubMed:8798755). Lower levels in trachea, prostate, stomach and spinal cord (PubMed:8798755). {ECO:0000269|PubMed:8798755, ECO:0000269|PubMed:8954911}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2QEP  (X-ray  2.50A  )  4HTI  (X-ray  1.95A  )  4HTJ  (X-ray  2.01A  ) 
DBSNP rs3800855  rs1130495  rs1130496  rs1130499  rs3752368  rs7456452  rs577236042 
Subcellular location [CC]Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P80560};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P80560}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P80560};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P80560}. Note=Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity). {ECO:0000250|UniProtKB:P80560, ECO:0000250|UniProtKB:Q63475}.;
[IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}.
Mouse PG classificationNA
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