| Gene Information | |
|---|---|
| Gene Name | GJC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 279 |
| Protein Names | Gap junction gamma-3 protein (Connexin-30.2) (Cx30.2) (Connexin-31.3) (Cx31.3) (Gap junction epsilon-1 protein) |
| Target Name | gap junction gamma-3 protein |
| Target Type | Literature-reported target |
| Gene Age | 454 ( ENSG00000176402 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8NFK1 |
| Gene Card | GJC3 |
| Uniprot ID | Q8NFK1 |
| Pfam | PF00029 |
| In ASD | no |
| Allosteric Prediction | no (-1.017284308) |
| Ortholog in Animals | Alpaca_ GJC3 ( ortholog_one2one ) Dog_ GJC3 ( ortholog_one2many ) GuineaPig_ GJC3 ( ortholog_one2one ) Macaque_ GJC3 ( ortholog_one2one ) Mouse_ Gjc3 ( ortholog_one2one ) Pig_ GJC3 ( ortholog_one2one ) Rat_ Gjc3 ( ortholog_one2one ) Rabbit_ GJC3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GJA10, GJA9, GJD2, GJD3, GJA4, GJA1, GJA8, GJA5, GJA3, GJB3, GJB1, GJB2, GJB5, GJB4, GJB6, GJB7, GJC2, GJC1, GJD4, GJE1 |
| Tissue | tibial.nerve |
| Tissue Specificity | CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve. According to PubMed:12881038, expression is abundant in skeletal muscle, liver, and heart, and to a minor degree in pancreas and kidney. {ECO:0000269|PubMed:12151525, ECO:0000269|PubMed:12881038}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6L3T (EM 2.34A ) 6L3U (EM 2.53A ) 6L3V (EM 2.63A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}. |
| Mouse PG classification | NA |
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