| Gene Information | |
|---|---|
| Gene Name | GJC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 439 |
| Protein Names | Gap junction gamma-2 protein (Connexin-46.6) (Cx46.6) (Connexin-47) (Cx47) (Gap junction alpha-12 protein) |
| Target Name | gap junction gamma-2 protein |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000198835 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5T442 |
| Gene Card | GJC2 |
| Uniprot ID | Q5T442 |
| Pfam | PF00029 |
| In ASD | no |
| Allosteric Prediction | no (-0.64693398) |
| Ortholog in Animals | Alpaca_ GJC2 ( ortholog_one2one ) Dog_ GJC2 ( ortholog_one2one ) GuineaPig_ GJC2 ( ortholog_one2one ) Macaque_ GJC2 ( ortholog_one2one ) Mouse_ Gjc2 ( ortholog_one2one ) Pig_ GJC2 ( ortholog_one2one ) Rat_ Gjc2 ( ortholog_one2one ) |
| Ohnologs | GJA8 |
| Paralogs | GJC1, GJD4, GJE1, GJA4, GJA1, GJA8, GJA5, GJA3, GJB3, GJB1, GJB2, GJB5, GJB4, GJB6, GJB7, GJA10, GJA9, GJD2, GJD3, GJC3 |
| Tissue | NA |
| Tissue Specificity | Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles. {ECO:0000269|PubMed:15192806}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs149590094 rs75469429 rs267606847 rs74315312 rs577325764 rs267606846 rs74315314 rs74315311 rs760502262 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. |
| Mouse PG classification | NA |
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