| Gene Information | |
|---|---|
| Gene Name | CD1C |
| Organism | Homo sapiens (Human) |
| Gene Length | 333 |
| Protein Names | T-cell surface glycoprotein CD1c (CD antigen CD1c) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000158481 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P29017 |
| Gene Card | CD1C |
| Uniprot ID | P29017 |
| Pfam | PF07654; PF16497 |
| In ASD | no |
| Allosteric Prediction | yes (0.17419672) |
| Ortholog in Animals | Alpaca_ CD1C ( ortholog_one2one ) Dog_ CD1B ( ortholog_one2one ) Macaque_ CD1C ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HLA-B, HLA-E, HLA-A, HLA-F, HLA-G, HLA-C, MR1, AZGP1, MICA, HFE, MICB, CD1A, CD1D, CD1E, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, RAET1E, ULBP3, ULBP1 |
| Tissue | spleen |
| Tissue Specificity | Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3OV6 (X-ray 2.50A ) 4ONO (X-ray 2.70A ) 5C9J (X-ray 2.40A ) 6C09 (X-ray 2.95A ) 6C15 (X-ray 3.21A ) |
| DBSNP | rs3138100 rs3138105 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:3097645}; Single-pass type I membrane protein. Lysosome {ECO:0000269|PubMed:10890914}. Note=Subject to intracellular trafficking between the cell membrane and endosomes. {ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:3097645}. |
| Mouse PG classification | NA |
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