| Gene Information | |
|---|---|
| Gene Name | GJB4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 266 |
| Protein Names | Gap junction beta-4 protein (Connexin-30.3) (Cx30.3) |
| Target Name | gap junction beta-4 protein |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000189433 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NTQ9 |
| Gene Card | GJB4 |
| Uniprot ID | Q9NTQ9 |
| Pfam | PF00029 |
| In ASD | no |
| Allosteric Prediction | no (-0.711455925) |
| Ortholog in Animals | Alpaca_ GJB4 ( ortholog_one2one ) Dog_ GJB4 ( ortholog_one2one ) GuineaPig_ GJB4 ( ortholog_one2one ) Macaque_ GJB4 ( ortholog_one2one ) Mouse_ Gjb4 ( ortholog_one2one ) Pig_ GJB4 ( ortholog_one2one ) Rat_ Gjb4 ( ortholog_one2one ) Rabbit_ GJB4 ( ortholog_one2one ) |
| Ohnologs | GJB6, GJB7, GJB2, GJB1 |
| Paralogs | GJB5, GJB3, GJB7, GJB1, GJB2, GJB6, GJA4, GJA1, GJA8, GJA5, GJA3, GJA10, GJA9, GJD2, GJD3, GJC3, GJC2, GJC1, GJD4, GJE1 |
| Tissue | skin, zone.of.skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs80358211 rs80358212 rs80358210 rs9426009 rs140996335 rs80358206 rs148710003 rs79193415 rs80358213 rs3738346 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q02738}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02738}. Cell junction, gap junction {ECO:0000250|UniProtKB:Q02738}. Note=Colocalizes with GJB2 at gap junction plaques in the cochlea. {ECO:0000250|UniProtKB:Q02738}. |
| Mouse PG classification | NA |
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