| Gene Information | |
|---|---|
| Gene Name | GJA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 435 |
| Protein Names | Gap junction alpha-3 protein (Connexin-46) (Cx46) |
| Target Name | gap junction alpha-3 protein |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000121743 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y6H8 |
| Gene Card | GJA3 |
| Uniprot ID | Q9Y6H8 |
| Pfam | PF00029 |
| In ASD | no |
| Allosteric Prediction | no (-0.841412726) |
| Ortholog in Animals | Alpaca_ GJA3 ( ortholog_one2one ) Dog_ GJA3 ( ortholog_one2one ) Macaque_ GJA3 ( ortholog_one2one ) Mouse_ Gja3 ( ortholog_one2one ) Pig_ GJA3 ( ortholog_one2one ) Rat_ Gja3 ( ortholog_one2one ) Rabbit_ GJA3 ( ortholog_one2one ) |
| Ohnologs | GJA9, GJA10, GJA1, GJA1P1, GJA4 |
| Paralogs | GJB3, GJB1, GJB2, GJB5, GJB4, GJB6, GJB7, GJA10, GJA9, GJD2, GJD3, GJC3, GJC2, GJC1, GJD4, GJE1, GJA4, GJA1, GJA8, GJA5 |
| Tissue | heart, left.atrium, left.ventricle, mitral.valve, pulmonary.valve, tricuspid.valve |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs397514703 rs1114167307 rs1555339539 rs981126461 rs864309691 rs121917823 rs121917827 rs864309687 rs1114167308 rs121917825 rs140332366 rs140332366 rs968566 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:30044662}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9TU17}. Cell junction, gap junction {ECO:0000269|PubMed:30044662}. |
| Mouse PG classification | NA |
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