| Gene Information | |
|---|---|
| Gene Name | GRM7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 915 |
| Protein Names | Metabotropic glutamate receptor 7 (mGluR7) |
| Target Name | metabotropic glutamate receptor 7 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000196277 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14831 |
| Gene Card | GRM7 |
| Uniprot ID | Q14831 |
| Pfam | PF00003; PF01094; PF07562 |
| In ASD | yes |
| Allosteric Prediction | yes (1.872347833) |
| Ortholog in Animals | Alpaca_ GRM7 ( ortholog_one2one ) Dog_ GRM7 ( ortholog_one2one ) GuineaPig_ GRM7 ( ortholog_one2one ) Macaque_ GRM7 ( ortholog_one2one ) Mouse_ Grm7 ( ortholog_one2one ) Pig_ GRM7 ( ortholog_one2one ) Rat_ Grm7 ( ortholog_one2one ) Rabbit_ GRM7 ( ortholog_one2one ) |
| Ohnologs | GRM4, GRM5, GRM8 |
| Paralogs | GRM2, GRM1, GRM5, GRM3, GRM6, GRM8, GRM4 |
| Tissue | NA |
| Tissue Specificity | Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. {ECO:0000269|PubMed:12052533, ECO:0000269|PubMed:8840028}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3MQ4 (X-ray 2.80A ) 5C5C (X-ray 1.86A ) 7EPC (EM 4.00A ) 7EPD (EM 3.90A ) |
| DBSNP | rs1114167298 rs2229902 rs7634846 rs769709112 rs1114167300 rs1114167301 rs1485174 rs746833089 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:33500274}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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