| Gene Information | |
|---|---|
| Gene Name | GIG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 563 |
| Protein Names | Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Cell growth-inhibiting gene 1 protein) (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O14773 |
| Gene Card | TPP1 |
| Uniprot ID | O14773 |
| Pfam | PF00082; PF09286 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3EDY (X-ray 1.85A ) 3EE6 (X-ray 2.35A ) |
| DBSNP | rs2734715 rs121908195 rs1800746 rs121908204 rs1554902028 rs764922748 rs34758634 rs121908205 rs28940573 rs121908209 rs1218678626 rs757953998 rs121908207 rs796053439 rs796053439 rs119455957 rs119455958 rs121908196 rs765380155 rs121908197 rs121908206 rs119455953 rs119455954 rs121908198 rs121908199 rs121908200 rs119455956 rs121908201 rs398122959 rs121908203 rs121908202 rs121908208 rs121908210 rs1348967263 |
| Subcellular location [CC] | Lysosome {ECO:0000269|PubMed:19941651}. Melanosome {ECO:0000269|PubMed:12643545}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}. |
| Mouse PG classification | NA |
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