Gene Information
Gene NameCRACR2A
OrganismHomo sapiens (Human)
Gene Length731
Protein NamesEF-hand calcium-binding domain-containing protein 4B (Calcium release-activated calcium channel regulator 2A) (CRAC channel regulator 2A) (Calcium release-activated channel regulator 2A) (Ras-related protein Rab-46)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000130038 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9BSW2
Gene CardCRACR2A
Uniprot IDQ9BSW2
PfamPF13499; PF00071
In ASDno
Allosteric Predictionno (-0.342887294)
Ortholog in AnimalsAlpaca_ CRACR2A ( ortholog_one2one )
Dog_ CRACR2A ( ortholog_one2one )
GuineaPig_ CRACR2A ( ortholog_one2one )
Macaque_ CRACR2A ( ortholog_one2one )
Mouse_ Cracr2a ( ortholog_one2one )
Pig_ CRACR2A ( ortholog_one2one )
Rat_ Cracr2a ( ortholog_one2one )
Rabbit_ CRACR2A ( ortholog_one2one )
OhnologsNA
ParalogsCRACR2B
Tissueparotid.gland, submandibular.gland
Tissue Specificity[Isoform 1]: Expressed in the Jurkat T-cell line. {ECO:0000269|PubMed:27016526}.;
[Isoform 2]: Expressed in endothelial cells (PubMed:25475730). Expressed in Weibel-Palade bodies (which are P-selectin/SELP negative) in endothelial cells (PubMed:31092558). Expressed in the Jurkat T-cell line (PubMed:30814157, PubMed:27016526). {ECO:0000269|PubMed:25475730, ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}.
Pharmacological Animal Models0.031082(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6PSD  (X-ray  2.66A  ) 
DBSNP rs9788233  rs17836273  rs242017  rs34088152  rs242018  rs36030417 
Subcellular location [CC][Isoform 1]: Cytoplasm {ECO:0000269|PubMed:20418871}.;
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}. Cell membrane {ECO:0000269|PubMed:30814157}. Golgi apparatus membrane {ECO:0000269|PubMed:27016526}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27016526}. Vesicle {ECO:0000269|PubMed:27016526}. Note=T-cell activation-induced elevation of intracellular of Ca(2+) stimulates its transport toward the microtubule organizing center (MTOC) (PubMed:30814157). Histamine stimulation induces a trafficking to the MTOC in a GTP-binding-dependent but Ca(2+)-binding-independent manner (PubMed:31092558). Localizes to Golgi membrane in resting T-cells and upon its interaction with VAV1, is translocated from the Golgi membrane to the immunological synapse via subsynaptic vesicles (PubMed:27016526). Its localization in the Golgi membrane requires isoprenylation and GTP-binding (PubMed:27016526). {ECO:0000269|PubMed:27016526, ECO:0000269|PubMed:30814157, ECO:0000269|PubMed:31092558}.
Mouse PG classificationNA
click here to return to the previous page