| Gene Information | |
|---|---|
| Gene Name | GHSR |
| Organism | Homo sapiens (Human) |
| Gene Length | 366 |
| Protein Names | Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) |
| Target Name | growth hormone secretagogue receptor 1 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000121853 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q92847 |
| Gene Card | GHSR |
| Uniprot ID | Q92847 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.240595968) |
| Ortholog in Animals | Alpaca_ GHSR ( ortholog_one2one ) Dog_ GHSR ( ortholog_one2one ) GuineaPig_ GHSR ( ortholog_one2one ) Macaque_ GHSR ( ortholog_one2one ) Mouse_ Ghsr ( ortholog_one2one ) Pig_ GHSR ( ortholog_one2one ) Rat_ Ghsr ( ortholog_one2one ) Rabbit_ GHSR ( ortholog_one2one ) |
| Ohnologs | NMUR2, NMUR1 |
| Paralogs | BRS3, NMBR, EDNRA, GRPR, EDNRB, GPR37, TRHR, GPR148, GPR37L1, MLNR, NTSR1, NTSR2, GPR39, NMUR2, NMUR1 |
| Tissue | NA |
| Tissue Specificity | Pituitary and hypothalamus. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6KO5 (X-ray 3.30A ) 7F9Y (EM 2.90A ) 7F9Z (EM 3.20A ) 7NA7 (EM 2.70A ) 7NA8 (EM 2.70A ) 7W2Z (EM 2.80A ) |
| DBSNP | rs2232165 rs121917883 rs199588904 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | LPG |
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