Gene Information
Gene NameGGTB2
OrganismHomo sapiens (Human)
Gene Length398
Protein NamesBeta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (Neolactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP15291
Gene CardB4GALT1
Uniprot IDP15291
PfamPF02709; PF13733
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitously expressed, but at very low levels in fetal and adult brain.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2AE7  (X-ray  2.00A  )  2AEC  (X-ray  2.00A  )  2AES  (X-ray  2.00A  )  2AGD  (X-ray  1.90A  )  2AH9  (X-ray  2.00A  )  2FY7  (X-ray  1.70A  )  2FYA  (X-ray  1.90A  )  2FYB  (X-ray  1.90A  )  3EE5  (X-ray  2.20A  )  4EE3  (X-ray  2.30A  )  4EE4  (X-ray  1.95A  )  4EE5  (X-ray  2.20A  )  4EEA  (X-ray  2.00A  )  4EEG  (X-ray  2.20A  )  4EEM  (X-ray  2.20A  )  4EEO  (X-ray  2.30A  )  4L41  (X-ray  2.70A  )  6FWT  (X-ray  1.84A  )  6FWU  (X-ray  2.35A  ) 
DBSNP rs1065764  rs9169 
Subcellular location [CC][Isoform Long]: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:1714903, ECO:0000269|PubMed:20378551};
Single-pass type II membrane protein. Cell membrane {ECO:0000269|PubMed:1714903};
Single-pass type II membrane protein. Cell surface {ECO:0000269|PubMed:1714903}. Cell projection, filopodium {ECO:0000250|UniProtKB:P15535}. Note=Found in trans cisternae of Golgi but is mainly localized at the plasma membrane (PubMed:1714903). B4GALT1 cell surface expression is regulated by UBE2Q1 (By similarity). {ECO:0000250|UniProtKB:P15535, ECO:0000269|PubMed:1714903}.;
[Isoform Short]: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:1714903};
Single-pass type II membrane protein. Note=Found in trans cisternae of Golgi. {ECO:0000269|PubMed:1714903}.;
[Processed beta-1,4-galactosyltransferase 1]: Secreted {ECO:0000303|PubMed:2120039}. Note=Soluble form found in body fluids. {ECO:0000303|PubMed:2120039}.
Mouse PG classificationNA
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