| Gene Information | |
|---|---|
| Gene Name | MTUS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1270 |
| Protein Names | Microtubule-associated tumor suppressor 1 (AT2 receptor-binding protein) (Angiotensin-II type 2 receptor-interacting protein) (Mitochondrial tumor suppressor 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000129422 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9ULD2 |
| Gene Card | MTUS1 |
| Uniprot ID | Q9ULD2 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.79634646) |
| Ortholog in Animals | Alpaca_ MTUS1 ( ortholog_one2one ) Dog_ MTUS1 ( ortholog_one2one ) GuineaPig_ MTUS1 ( ortholog_one2one ) Macaque_ MTUS1 ( ortholog_one2one ) Mouse_ Mtus1 ( ortholog_one2one ) Pig_ MTUS1 ( ortholog_one2one ) Rat_ Mtus1 ( ortholog_one2one ) Rabbit_ MTUS1 ( ortholog_one2one ) |
| Ohnologs | MTUS2 |
| Paralogs | CCDC69, MTUS2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. {ECO:0000269|PubMed:10697957, ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:15123706, ECO:0000269|PubMed:16270321, ECO:0000269|PubMed:16887298, ECO:0000269|PubMed:16969489, ECO:0000269|PubMed:17656251}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs61733703 rs3739407 rs141609607 rs61733694 rs17690844 rs209569 rs187103704 rs61748836 rs17853231 rs61733705 rs567116808 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:10697957, ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis. |
| Mouse PG classification | NA |
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