| Gene Information | |
|---|---|
| Gene Name | GGT |
| Organism | Homo sapiens (Human) |
| Gene Length | 569 |
| Protein Names | Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P19440 |
| Gene Card | GGT1 |
| Uniprot ID | P19440 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.; [Isoform 3]: Lung-specific. {ECO:0000269|PubMed:7689219}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4GDX (X-ray 1.67A ) 4GG2 (X-ray 2.21A ) 4Z9O (X-ray 2.30A ) 4ZBK (X-ray 2.18A ) 4ZC6 (X-ray 2.10A ) 4ZCG (X-ray 2.22A ) 5V4Q (X-ray 2.20A ) |
| DBSNP | rs2330837 rs2330838 rs3895576 rs4049829 rs17004876 rs1062459 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23682772, ECO:0000269|PubMed:8095045}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P07314}. |
| Mouse PG classification | NA |
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