| Gene Information | |
|---|---|
| Gene Name | GGH |
| Organism | Homo sapiens (Human) |
| Gene Length | 318 |
| Protein Names | Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000137563 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92820 |
| Gene Card | GGH |
| Uniprot ID | Q92820 |
| Pfam | PF07722 |
| In ASD | no |
| Allosteric Prediction | yes (0.426832082) |
| Ortholog in Animals | Alpaca_ GGH ( ortholog_one2one ) Dog_ GGH ( ortholog_one2one ) GuineaPig_ GGH ( ortholog_one2one ) Macaque_ GGH ( ortholog_one2one ) Mouse_ Ggh ( ortholog_one2one ) Pig_ GGH ( ortholog_one2one ) Rat_ Ggh ( ortholog_one2one ) Rabbit_ GGH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1L9X (X-ray 1.60A ) |
| DBSNP | rs1800909 rs11545077 rs11545078 |
| Subcellular location [CC] | Secreted, extracellular space {ECO:0000305}. Lysosome {ECO:0000269|PubMed:12643545}. Melanosome {ECO:0000269|PubMed:12643545}. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}. |
| Mouse PG classification | NA |
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