| Gene Information | |
|---|---|
| Gene Name | GFRA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 464 |
| Protein Names | GDNF family receptor alpha-2 (GDNF receptor alpha-2) (GDNFR-alpha-2) (GFR-alpha-2) (GDNF receptor beta) (GDNFR-beta) (Neurturin receptor alpha) (NRTNR-alpha) (NTNR-alpha) (RET ligand 2) (TGF-beta-related neurotrophic factor receptor 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000168546 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O00451 |
| Gene Card | GFRA2 |
| Uniprot ID | O00451 |
| Pfam | PF02351 |
| In ASD | no |
| Allosteric Prediction | no (-0.115010208) |
| Ortholog in Animals | Alpaca_ GFRA2 ( ortholog_one2one ) Dog_ GFRA2 ( ortholog_one2one ) GuineaPig_ GFRA2 ( ortholog_one2one ) Macaque_ GFRA2 ( ortholog_one2one ) Mouse_ Gfra2 ( ortholog_one2one ) Pig_ GFRA2 ( ortholog_one2one ) Rat_ Gfra2 ( ortholog_one2one ) Rabbit_ GFRA2 ( ortholog_one2one ) |
| Ohnologs | GFRA1 |
| Paralogs | GFRA1, GFRA4, GFRA3, GFRAL |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is found in both brain and placenta. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.070650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5MR4 (X-ray 2.40A ) 5MR5 (X-ray 2.00A ) 6GL7 (EM 6.30A ) 6Q2O (EM 3.65A ) 6Q2R (EM 4.30A ) |
| DBSNP | rs1128397 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. |
| Mouse PG classification | NA |
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