| Gene Information | |
|---|---|
| Gene Name | TMEM98 |
| Organism | Homo sapiens (Human) |
| Gene Length | 226 |
| Protein Names | Transmembrane protein 98 (Protein TADA1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000006042 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y2Y6 |
| Gene Card | TMEM98 |
| Uniprot ID | Q9Y2Y6 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.493361829) |
| Ortholog in Animals | Alpaca_ TMEM98 ( ortholog_one2one ) Dog_ TMEM98 ( ortholog_one2one ) GuineaPig_ TMEM98 ( ortholog_one2one ) Macaque_ TMEM98 ( ortholog_one2one ) Mouse_ Tmem98 ( ortholog_one2one ) Pig_ TMEM98 ( ortholog_one2one ) Rat_ Tmem98 ( ortholog_one2one ) Rabbit_ TMEM98 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | substantia.nigra |
| Tissue Specificity | Widely expressed with high expression in the ovary, pancreas and prostate (PubMed:25946230). Expressed in the eye, particularly in corneal endothelium, iris, ciliary body, sclera, optic nerve, optic nerve head, and retina (PubMed:24852644). Expressed by activated peripheral blood mononuclear cells (PubMed:25946230). {ECO:0000269|PubMed:24852644, ECO:0000269|PubMed:25946230}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs35124349 rs587777690 rs869312733 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25946230}; Single-pass type II membrane protein {ECO:0000269|PubMed:25946230}. Secreted {ECO:0000269|PubMed:25946230}. Secreted, extracellular exosome {ECO:0000269|PubMed:25946230}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91X86}; Single-pass type II membrane protein {ECO:0000269|PubMed:25946230}. Note=Secreted by exosomes through a non-classical pathway. {ECO:0000269|PubMed:25946230}. |
| Mouse PG classification | NA |
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