| Gene Information | |
|---|---|
| Gene Name | POFUT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 429 |
| Protein Names | GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000186866 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y2G5 |
| Gene Card | POFUT2 |
| Uniprot ID | Q9Y2G5 |
| Pfam | PF10250 |
| In ASD | no |
| Allosteric Prediction | no (-0.90045543) |
| Ortholog in Animals | Alpaca_ POFUT2 ( ortholog_one2one ) Dog_ POFUT2 ( ortholog_one2one ) GuineaPig_ POFUT2 ( ortholog_one2one ) Macaque_ POFUT2 ( ortholog_one2one ) Mouse_ Pofut2 ( ortholog_one2one ) Rat_ Pofut2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart. {ECO:0000269|PubMed:15233996}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4AP5 (X-ray 3.00A ) 4AP6 (X-ray 3.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000269|PubMed:15233996}. Golgi apparatus {ECO:0000269|PubMed:15233996}. Note=Mainly located in the endoplasmic reticulum. {ECO:0000269|PubMed:15233996}. |
| Mouse PG classification | NA |
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