| Gene Information | |
|---|---|
| Gene Name | ATP8B2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1209 |
| Protein Names | Phospholipid-transporting ATPase ID (EC 7.6.2.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000143515 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P98198 |
| Gene Card | ATP8B2 |
| Uniprot ID | P98198 |
| Pfam | PF16212; PF16209 |
| In ASD | no |
| Allosteric Prediction | no (-0.837672697) |
| Ortholog in Animals | Alpaca_ ATP8B2 ( ortholog_one2one ) Dog_ ATP8B2 ( ortholog_one2one ) GuineaPig_ ATP8B2 ( ortholog_one2one ) Macaque_ ATP8B2 ( ortholog_one2one ) Mouse_ Atp8b2 ( ortholog_one2one ) Pig_ ATP8B2 ( ortholog_one2one ) Rat_ Atp8b2 ( ortholog_one2one ) |
| Ohnologs | ATP8B1, ATP8B4, ATP8B3 |
| Paralogs | ATP8B4, ATP10D, ATP11A, ATP8A2, ATP11C, ATP10A, ATP11B, ATP8B1, ATP9A, ATP10B, ATP8A1, ATP9B, ATP8B3 |
| Tissue | NA |
| Tissue Specificity | Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus. {ECO:0000269|PubMed:12880872}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:25315773}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20961850}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A or TMEM30B. {ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:25315773}. |
| Mouse PG classification | NA |
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