| Gene Information | |
|---|---|
| Gene Name | GDF15 |
| Organism | Homo sapiens (Human) |
| Gene Length | 308 |
| Protein Names | Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000130513 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q99988 |
| Gene Card | GDF15 |
| Uniprot ID | Q99988 |
| Pfam | PF00019 |
| In ASD | no |
| Allosteric Prediction | yes (0.286613231) |
| Ortholog in Animals | Alpaca_ GDF15 ( ortholog_one2one ) Dog_ GDF15 ( ortholog_one2one ) GuineaPig_ GDF15 ( ortholog_one2one ) Macaque_ GDF15 ( ortholog_one2one ) Mouse_ Gdf15 ( ortholog_one2one ) Pig_ GDF15 ( ortholog_one2one ) Rat_ Gdf15 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BMP3, MSTN, INHBC, BMP6, INHBA, GDF6, TGFB3, BMP2, BMP10, TGFB1, INHA, GDF9, GDF11, BMP5, BMP7, INHBB, GDF5, GDF1, GDF2, BMP4, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, TGFB2, BMP8A, BMP8B, NODAL |
| Tissue | kidney |
| Tissue Specificity | Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney (PubMed:9348093). Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435). {ECO:0000269|PubMed:28572090, ECO:0000269|PubMed:29046435, ECO:0000269|PubMed:9348093}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5VT2 (X-ray 2.30A ) 5VZ3 (X-ray 1.97A ) 5VZ4 (X-ray 2.20A ) 6Q2J (EM 4.10A ) |
| DBSNP | rs1059519 rs1059369 rs1058587 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:28572090, ECO:0000269|PubMed:29046435}. |
| Mouse PG classification | NA |
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